Regulation of Prostate Development and Benign Prostatic Hyperplasia by Autocrine Cholinergic Signaling via Maintaining the Epithelial Progenitor Cells in Proliferating Status
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- 作者：Naitao Wang1 ; 4 ; Bai-Jun Dong2 ; 4 ; Yizhou Quan1 ; Qianqian Chen1 ; Mingliang Chu1 ; Jin Xu1 ; Wei Xue2 ; Yi-Ran Huang2 ; Ru Yang1 ; 5 ; yangru@yahoo.com" class="auth_mail" title="E-mail the corresponding author ; Wei-Qiang Gao1 ; 3 ; 5 ; gao.weiqiang@sjtu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：autocrine cholinergic signaling ; CHRM3 ; prostatic branching morphogenesis ; epithelial progenitor cells ; BPH
- 刊名：Stem Cell Reports
- 出版年：2016
- 出版时间：10 May 2016
- 年：2016
- 卷：6
- 期：5
- 页码：668-678
- 全文大小：3113 K
文摘
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There is autocrine cholinergic signaling (ACS) in developing mouse prostate
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ACS regulates proliferation and differentiation of prostate epithelial progenitors
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ACS regulates prostate development through calcium signaling
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CHRM3 is upregulated in a subset of BPH tissues compared with normal tissues