Live-vaccinia virus encapsulation in pH-sensitive polymer increases safety of a reservoir-targeted Lyme disease vaccine by targeting gastrointestinal release
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- 作者：Aurelie Kerna ; Chensheng W. Zhoub ; Feng Jiab ; Qiaobing Xub ; Linden T. Hua ; linden.hu@tufts.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Reservoir-targeted vaccine ; Lyme disease ; Polymethylacrylate ; Safety ; Encapsulation ; Borrelia burgdorferi
- 刊名：Vaccine
- 出版年：2016
- 出版时间：31 August 2016
- 年：2016
- 卷：34
- 期：38
- 页码：4507-4513
- 全文大小：880 K
文摘
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Reservoir-targeted vaccination is a promising method for preventing Lyme disease.
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Virally vectored vaccines are highly immunogenic but pose an exposure risk for humans.
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Coating with a pH-sensitive polymer targets gastrointestinal release of the virus.
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Polymer coatings increase safety of vaccinia vaccines by preventing unwanted exposure.
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Encapsulation with a pH sensitive polymer does not reduce efficacy of the vaccine.