MiR-564 functions as a tumor suppressor in human lung cancer by targeting ZIC3
详细信息 查看全文
- 作者：Bin Yanga ; 1 ; Lin Jiab ; 1 ; Qiaojuan Guoc ; Hui Rena ; Desheng Hua ; Xiaoyi Zhoua ; Qingrong Rena ; Yanping Hua ; huyp1989@163.com" class="auth_mail" title="E-mail the corresponding author ; Tao Xied ; xietao930@hotmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：miR-564 ; ZIC3 ; Proliferation ; Invasion ; Tumor suppressor ; Lung cancer
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2015
- 出版时间：27 November 2015
- 年：2015
- 卷：467
- 期：4
- 页码：690-696
- 全文大小：1639 K
文摘
- •
MiR-564 inhibits cancer cell proliferation, cell cycle progression, migration, and invasion.
- •
miR-564 suppresses the tumorigenicity of lung cancer cell in vivo.
- •
ZIC3 is a direct and functional target of miR-564.
- •
The expression of miR-564 was negatively correlated with ZIC3 protein in tumors.
- •
Both low miR-564 and high ZIC3 was associated with tumor stage and prognosis.