Double axially chiral bisphosphorylimides as novel Br?nsted acids in asymmetric three-component Mannich reaction

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• 作者：Ying-Ying Chen ; Yi-Jun Jiang ; Yan-Sen Fan ; Di Sha ; Qifeng Wang ; Guangliang Zhang ; Liangyu Zheng ; Suoqin Zhang
• 刊名：Tetrahedron: Asymmetry
• 出版年：2012
• 出版时间：30 June, 2012
• 年：2012
• 卷：23
• 期：11-12
• 页码：904-909
• 全文大小：550 K

文摘

A double axially chiral bisphosphorylimide has been demonstrated to be an efficient and highly sterically hindered Br?nsted acid in asymmetric three-component Mannich reactions. Optically active syn-¦Â-amino ketones were obtained in high yields (up to 99 % ) with excellent diastereoselectivity (99:1) and enantioselectivity (up to 99 % ee). A gram-scale reaction was also performed to prove the synthetic application value of this reaction.