iTRAQ-based comparative proteomic analysis of Vero cells infected with virulent and CV777 vaccine strain-like strains of porcine epidemic diarrhea virus
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- 作者：Xiaozhen Guoa ; Han Hua ; Fangzhou Chena ; Zhonghua Lia ; Shiyi Yea ; Shuang Chengb ; Mengjia Zhanga ; Qigai Hea ; he628@mail.hzau.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Porcine epidemic diarrhea virus (PEDV) ; Isobaric tags for relative and absolute quantitation (iTRAQ) ; Proteomics ; Pathway analysis
- 刊名：Journal of Proteomics
- 出版年：2016
- 出版时间：1 January 2016
- 年：2016
- 卷：130
- 期：Complete
- 页码：65-75
- 全文大小：1704 K
文摘
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Vero cells proteome was individually analyzed upon virulent and attenuated PEDV infections.
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Many pathways and interactive networks were constructed based on differentially expressed proteins.
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Virulent PEDV strain suppressed mTOR as well as its downstream targets 4EBP1 and p70S6K activities.
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Virulent PEDV strain activated NF-κB pathway more intensively than the attenuated isolate.