Storage and delivery of nitric oxide via diazeniumdiolated metal organic framework

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• 作者：Alysia Lowe ; Punya Chittajallu ; Qihan Gong ; Jing Li ; Kenneth J. Balkus Jr.
• 关键词：Nitric oxide ; Diazeniumdiolate ; Wound healing ; Metal organic framework
• 刊名：Microporous and Mesoporous Materials
• 出版年：2013
• 出版时间：15 November, 2013
• 年：2013
• 卷：181
• 期：Complete
• 页码：17-22
• 全文大小：2028 K

文摘

Metal-organic frameworks (MOFs) are generally explored for gas adsorption and separation but more recently they have been studied for use in biomedical applications. The present study focuses on the incorporation of a nitric oxide (NO) donor, called a diazeniumdiolate (NONOate), into a new MOF using a one-step post-synthetic method. The MOF, Cu-TDPAT, contains copper nodes linked by 2,4,6-tris(3,5-dicarboxylphenylamino)-1,3,5-triazine (H₆TDPAT). This MOF adsorbs NO and the TDPAT linker contains secondary amines which react with NO to form a NONOate. The covalently bound NONOate donor group allows for greater control over the NO storage and delivery rate. Over the course of 7 days, the Cu-TDPAT NONOate will yield approximately 175 ¦Ìmol/g NO by exposure to 85 % humidity and 53 ¦Ìmol/g NO by heating to 37 ¡ãC.