Anti-fatigue activity of polysaccharide fractions from Lepidium meyenii Walp. (maca)

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• 作者：Jing Li^a ; ^b ; ^c ; Qingrui Sun^b ; ^c ; Qingran Meng^b ; ^c ; Lei Wang^b ; ^c ; Wentao Xiong^d ; Lianfu Zhang^a ; ^b ; ^c ; ^{lianfu@jiangnan.edu.cn}
• 关键词：Maca (Lepidium meyenii Walp.) ; Polysaccharide ; Anti-fatigue
• 刊名：International Journal of Biological Macromolecules
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：95
• 期：Complete
• 页码：1305-1311
• 全文大小：619 K
• 卷排序：95

文摘

The two fractions of polysaccharide MPS-1 and MPS-2 were extracted from Lepidium meyenii Walp. (maca) by water, and purified using a DEAE-52 and a Sephadex G-100 column. The molecular weight (MW) of MPS-1 was 7.6 kDa, and the MW of MPS-2 was 6.7 kDa. The MPS-1 was composed of xylose, arabinose, galactose and glucose, with the mole ratio 1:1.7:3.3:30.5; the MPS-2 was composed of arabinose, galactose and glucose, with the mole ratio 1:1.3:36.8. The IR spectrum implied that only α-pyranose existed in MPS-1, and both α-pyranose and β-pyranose existed in MPS-2. The anti-fatigue activities of MPS-1 and MPS-2 were measured by the forced swimming test, along with the determination of blood lactate (BLA), urea nitrogen (BUN), lactic dehydrogenase (LDH) activity and liver glycogen (LG). The results indicated that both MPS-1 and MPS-2 presented dose-dependently positive effects on the fatigue related parameters. Additionally, MPS-2 has a better anti-fatigue effect than MPS-1.