A live, attenuated pseudorabies virus strain JS-2012 deleted for gE/gI protects against both classical and emerging strains
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- 作者：Wu Tonga ; b ; Guoxin Lia ; b ; Chao Lianga ; Fei Liua ; Qing Tiana ; Yanyun Caoa ; Lin Lia ; Xuchen Zhenga ; Hao Zhenga ; haozheng@shvri.ac.cn" class="auth_mail" title="E-mail the corresponding author ; Guangzhi Tonga ; b ; gztong@shvri.ac.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Pseudorabies virus ; gE/gI deletion ; Marker vaccine
- 刊名：Antiviral Research
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：130
- 期：Complete
- 页码：110-117
- 全文大小：1525 K
文摘
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A gE/gI deleted PRV strain JS-2012-△gE/gI was generated from a PRV variant strain using homologous DNA recombination.
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JS-2012-△gE/gI was avirulent to two-week-old suckling piglets.
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JS-2012-△gE/gI provided full protection for piglets against challenge of either the classical PRV or the PRV variant.
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Vaccinating sows with JS-2012-△gE/gI provided passive immunity to suckling piglets against challenge with the virulent strains.