Two new components from the rhizome of Anemarrhena asphodeloides Bge. and their antiplatelet aggregative activity

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• 作者：Yu Sun ; Linguang Li ; Chunting Liu ; Qingbo Liu ; Lingzhi Li ; Ying Peng ; Shaojiang Song
• 关键词：Anemarrhena asphodeloides Bge. ; Antiplatelet aggregative activity ; NMR data
• 刊名：Phytochemistry Letters
• 出版年：February, 2014
• 年：2014
• 卷：7
• 期：Complete
• 页码：207-211
• 全文大小：603 K

文摘

Two new components, anemarrhena A (1) and anemarrhena B (2), together with five known ones (3-7), were isolated from the rhizome of Anemarrhena asphodeloides Bge. Their structures were established by detailed spectral studies, including 1D-NMR (¹H NMR, ¹³C NMR and DEPT), 2D-NMR (HSQC, HMBC and NOESY), HR-ESI-MS and by the comparison with literature data. The absolute configuration of 2 was further determined by CD analysis. The isolated compounds were evaluated for their antiplatelet aggregative activity. Compounds 1, 2, 3, 5, 6 and 7 exhibited moderate activity of antiplatelet aggregation in vitro, compound 4 showed potential antiplatelet aggregation activity.