Decreased RECQL5 correlated with disease progression of osteosarcoma
详细信息 查看全文
- 作者：Junlong Wu1 ; Liqiang Zhi1 ; Xin Dai ; Qingchun Cai ; Wei Ma ; doctormawei@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：RECQL5 ; Osteosarcoma ; Proliferation ; Apoptosis ; Disease progression
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2015
- 出版时间：27 November 2015
- 年：2015
- 卷：467
- 期：4
- 页码：617-622
- 全文大小：1224 K
文摘
- •
The expression of RECQL5 was downregulated in osteosarcoma tissues and cells.
- •
Decreased RECQL5 correlated with osteosarcoma Enneking surgical classification.
- •
We constructed a stable RECQL5 overexpression cell line by CRISPR/Cas9 system.
- •
RECQL5 overexpression inhibited proliferation of MG-63 cells.
- •
RECQL5 overexpression promoted apoptosis of MG-63 cells.