Tumour necrosis factor-α inhibits hepatic lipid deposition through GSK-3β/β-catenin signaling in juvenile turbot (Scophthalmus maximus L.)
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- 作者：Dongwu Liu ; Kangsen Mai ; Yanjiao Zhang ; Wei Xu ; Qinghui Ai ; qhai@ouc.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Tumour necrosis factor-α ; Lipid deposition ; GSK-3β ; β-Catenin ; Liver ; Juvenile turbot
- 刊名：General and Comparative Endocrinology
- 出版年：2016
- 出版时间：1 March 2016
- 年：2016
- 卷：228
- 期：Complete
- 页码：1-8
- 全文大小：1487 K
文摘
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GSK-3β/β-catenin signaling was activated by TNFα in juvenile turbot.
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TNFα inhibited the expression of PPARγ and C/EBPα.
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TNFα inhibited the expression and activity of LPL and FAS.
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TNFα inhibits hepatic lipid deposition through GSK-3β/β-catenin signaling.