SERCA2a was serotonylated and may regulate sino-atrial node pacemaker activity
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- 作者：Qingjie Wanga ; b ; Dong Wangb ; Gaoliang Yanb ; Yong Qiaob ; Ling Suna ; Boqian Zhub ; Xin Wanga ; wangxin_nmu@126.com" class="auth_mail" title="E-mail the corresponding author ; Chengchun Tangb ; tangchengchun@medmail.com.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Sino-atrial node ; Pacemaker activity ; Serotonylation ; Sarco(endo)plasmic reticulum Ca ATPase
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：18 November 2016
- 年：2016
- 卷：480
- 期：3
- 页码：492-497
- 全文大小：1627 K
文摘
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SERCA2a can be serotonylated in vitro by 5- hydroxytryptamine.
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Simulation studies revealed that changes of Ca2+ affinity of the SERCA2a pump caused either tachycardia or bradycardia.
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Decreased forward-mode or increased reversed-mode Ca2+ affinity of the SERCA pump lead to tachycardia.
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Increased forward-mode or decreased reversed-mode Ca2+ affinity of the SERCA pump lead to bradycardia.