MicroRNA-218 promotes high glucose-induced apoptosis in podocytes by targeting heme oxygenase-1
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- 作者：Haibo Yanga ; haiboyangsea@163.com" class="auth_mail" title="E-mail the corresponding author ; Qingjun Wangb ; Sutong Lia
- 关键词：Cell apoptosis ; Diabetic nephropathy ; HO-1 ; miRNAs ; Podocyte
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：18 March 2016
- 年：2016
- 卷：471
- 期：4
- 页码：582-588
- 全文大小：1174 K
文摘
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miR-218 is up-regulated in HG-treated podocytes.
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miR-218 promotes podocyte apoptosis.
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HO-1 is a target of miR-218.
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Knockdown of HO-1 blocks the anti-apoptotic effect of anti-miR-218 in podocytes.
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miR-218 regulates p38-MAPK phosphorylation.