Neutralizing epitopes mapping of human adenovirus type 14 hexon
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- 作者：Qiang Maa ; b ; 1 ; mat008@163.com" class="auth_mail" title="E-mail the corresponding author ; Xingui Tiana ; b ; 1 ; tianxingui7902@aliyun.com" class="auth_mail" title="E-mail the corresponding author ; Zaixue Jiangb ; 4931162@qq.com" class="auth_mail" title="E-mail the corresponding author ; Junfeng Huangc ; jfhuang.dg@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Qian Liub ; qianliu_ln@163.com" class="auth_mail" title="E-mail the corresponding author ; Xiaomei Lub ; lxm020@126.com" class="auth_mail" title="E-mail the corresponding author ; Qingming Luob ; 180115636@qq.com" class="auth_mail" title="E-mail the corresponding author ; Rong Zhoua ; zhourong@gird.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Adenovirus type 14 ; Neutralizing epitope ; Hexon ; Bivalent vaccine
- 刊名：Vaccine
- 出版年：2015
- 出版时间：27 November 2015
- 年：2015
- 卷：33
- 期：48
- 页码：6659-6665
- 全文大小：1101 K
文摘
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We predicted and identified four neutralizing epitopes of HAdV-14 hexon.
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The epitopes A14R2 and A14R4 were incorporated into the hexon of HAdV-3.
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The antisera against the chimeric viruses can neutralize both HAdV-14 and HAdV-3.
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The chimeric viruses could be HAdV-3/HAdV-14 bivalent vaccine candidates.