Piperazine-based polyurethane-ureas with controllable degradation as potential bone scaffolds

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• 作者：Changshun Ruan ; Nan Hu ; Yang Hu ; Lixin Jiang ; Qingqing Cai ; Huaiyu Wang ; Haobo Pan ; William W. Lu ; Yuanliang Wang
• 关键词：Piperazine-based polyurethane-urea ; In vitro degradation ; Controllable degradation
• 刊名：Polymer
• 出版年：25 February, 2014
• 年：2014
• 卷：55
• 期：4
• 页码：1020-1027
• 全文大小：1636 K

文摘

Piperazine-based polyurethane ureas (P-PUUs) with piperazine (PP) units as the functional ingredients have been designed to explore a novel polymeric biomaterial with the controllable degradation for bone repair in this study. P-PUUs were prepared upon the chain-growth polymerization of poly (d, l -lactic acid) diol (PDLLA diol), 1, 6-hexamethylene diisocyanate (HDI) where PP functioned as the chain extender. The investigation of in聽vitro degradation of P-PUUs was performed and the mechanical properties of P-PUUs during degradation were calculated. The results revealed that manipulating the ratio of PDLLA diol: HDI: PP could obtain the precise number of PP units (Num(pp)) in P-PUUs which may significantly impact the degradation stability and the degradation rate of P-PUUs. The negative linear correlation between the degradation rate and the Num(pp) of P-PUUs has been proved, suggesting the P-PUUs were endowed with controllable degradation. Such a linear correlation is expected to be applied to bone repair where the specific degradation rate of P-PUUs for the specific bone defect can be precisely predicted once the Num(pp) and the bone repairing period are known. Additionally, P-PUUs with higher Num(pp) exhibited remarkable mechanical properties during degradation which allowed polymers to provide more persistent mechanical support to bone repair.