Coxsackievirus A16-like particles produced in Pichia pastoris elicit high-titer neutralizing antibodies and confer protection against lethal viral challenge in mice
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- 作者：Chao Zhanga ; 1 ; Qingwei Liua ; 1 ; Zhiqiang Kua ; Yang Hua ; Xiaohua Yea ; Yingyi Zhangb ; Zhong Huanga ; huangzhong@ips.ac.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Coxsackievirus A16 ; Virus-like particle ; Vaccine ; Pichia pastoris
- 刊名：Antiviral Research
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：129
- 期：Complete
- 页码：47-51
- 全文大小：923 K
文摘
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CA16-VLPs were produced at relatively high levels in transgenic Pichia pastoris yeast.
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CA16-VLPs immunization induced the production of high-titer neutralizing antibodies in mice.
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Passive immunization with yeast-derived CA16-VLPs protected mice against viral challenge.