Hexon-modified recombinant E1-deleted adenoviral vectors as bivalent vaccine carriers for Coxsackievirus A16 and Enterovirus 71
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- 作者：Chao Zhang ; Yong Yang ; Yudan Chi ; Jieyun Yin ; Lijun Yan ; Zhiqiang Ku ; Qingwei Liu ; Zhong Huang ; huangzhong@ips.ac.cn" class="auth_mail" title="E-mail the corresponding author ; Dongming Zhou ; dmzhou@sibs.ac.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Ad ; adenovirus ; CA16 ; Coxsackievirus A16 ; EV71 ; Enterovirus 71 ; HFMD ; hand ; foot and mouth disease ; HVR ; hypervariable region
- 刊名：Vaccine
- 出版年：2015
- 出版时间：22 September 2015
- 年：2015
- 卷：33
- 期：39
- 页码：5087-5094
- 全文大小：1954 K
文摘
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We designed a bivalent vaccine for HFMD based on chimpanzee adenovirus serotype 68.
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Epitopes PEP71 and sSP70 were inserted into HVR1 and HVR2, respectively, of the hexon.
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Modelling studies revealed that the epitopes were well presented on the virion surface.
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Vaccination conferred protection against CA16 and EV71 to suckling mice.