PDGF-BB induces PRMT1 expression through ERK1/2 dependent STAT1 activation and regulates remodeling in primary human lung fibroblasts
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- 作者：Qingzhu Suna ; b ; Li Liua ; Jyotshna Mandalb ; Antonio Molinoc ; Daiana Stolzb ; Michael Tammb ; Shemin Lua ; Michael Rothb ; Michael.Roth@usb.ch" class="auth_mail" title="E-mail the corresponding author
- 关键词：Airway remodeling ; Primary lung fibroblast ; PRMT1 ; ERK ; STAT1
- 刊名：Cellular Signalling
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：28
- 期：4
- 页码：307-315
- 全文大小：1777 K
文摘
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PRMT1 regulates lung remodeling by fibroblasts.
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PDGF-BB regulates PRMT1 expression in human lung fibroblasts.
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PDGF-BB controls PRMT1 expression through ERK1/2 MAPK and STAT1.
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PRMT1 is a central regulator of lung remodeling and inflammation.
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PRMT1 presents a novel therapeutic target of airway wall remodeling in chronic lung diseases.