Cell-Cycle-Regulated Interaction between Mcm10 and Double Hexameric Mcm2-7 Is Required for Helicase Splitting and Activation during S Phase
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- 作者：Yun Quan1 ; 4 ; Yisui Xia1 ; 4 ; Lu Liu1 ; 4 ; Jiamin Cui1 ; Zhen Li1 ; Qinhong Cao1 ; Xiaojiang S. Chen3 ; Judith L. Campbell2 ; Huiqiang Lou1 ; lou@cau.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：DNA replication ; cell cycle ; helicase activation ; Mcm2-7 ; Mcm10
- 刊名：Cell Reports
- 出版年：2015
- 出版时间：22 December 2015
- 年：2015
- 卷：13
- 期：11
- 页码：2576-2586
- 全文大小：3502 K
文摘
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MCM undergoes cell-cycle-dependent change between double and single hexameric forms
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Mcm10 directly associates with the double hexameric MCM on chromatin
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Mcm10 C terminus-mediated MCM interaction is crucial in double hexamer splitting