Synthesis and optimization of novel allylated mono-carbonyl analogs of curcumin (MACs) act as potent anti-inflammatory agents against LPS-induced acute lung injury (ALI) in rats
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- 作者：Heping Zhua ; 1 ; Tingting Xua ; b ; 1 ; Chenyu Qiua ; 1 ; Beibei Wua ; b ; Yali Zhanga ; Lingfeng Chena ; Qinqin Xiaa ; Chenglong Lia ; Bin Zhoub ; pzhoubin@sina.com" class="auth_mail" title="E-mail the corresponding author ; Zhiguo Liua ; lzgcnu@163.com" class="auth_mail" title="E-mail the corresponding author ; Guang Lianga
- 关键词：Acute lung injury ; Water solubility ; Chemical stability ; Drug design ; Mono-carbonyl analogs of curcumin
- 刊名：European Journal of Medicinal Chemistry
- 出版年：2016
- 出版时间：4 October 2016
- 年：2016
- 卷：121
- 期：Complete
- 页码：181-193
- 全文大小：1965 K
文摘
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A novel series of allylated mono-carbonyl curcumin analogs were synthesized.
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Most of the compounds had significant water solubility as a hydrochloride salt.
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In vitro and in vivo anti-inflammatory experiments were performed.
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Compound 7a could be a lead compound as an ALI therapeutic agent.