The effect of Mycobacterium tuberculosis CRISPR-associated Cas2 (Rv2816c) on stress response genes expression, morphology and macrophage survival of Mycobacterium smegmatis
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- 作者：Qinqin Huang ; Hongping Luo ; Minqiang Liu ; Jie Zeng ; Abualgasim Elgaili Abdalla ; Xiangke Duan ; Qiming Li ; Jianping Xie ; georgex@swu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：CRISPR ; Cas2 ; Mycobacterium tuberculosis ; Stress response ; Sigma factors
- 刊名：Infection, Genetics and Evolution
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：40
- 期：Complete
- 页码：295-301
- 全文大小：1076 K
文摘
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Expression of Cas2 changes the cell envelope of Mycobacterium smegmatis.
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M. smegmatis expressing Cas2 is more sensitive to stress and antibiotics.
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Cas2 regulates transcriptions of stress response related genes sigB, sigE and sigH.
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Cas2 decreases the survival of M. smegmatis in macrophages.