Interleukin-32 contributes to invasion and metastasis of primary lung adenocarcinoma via NF-kappaB induced matrix metalloproteinases 2 and 9 expression

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• 作者：Qingli Zeng ; Shaoli Li ; Yanbin Zhou ; Weijun Ou ; Xingdong Cai ; Longjuan Zhang ; Wanling Huang ; Lixia Huang ; Qinqin Wang
• 关键词：IL-32 ; interleukin-32 ; NSCLC ; non-small cell lung carcinoma ; NF-魏B ; NF-kappaB ; MMP2 and MMP9 ; matrix metalloproteinase 2 and 9
• 刊名：Cytokine
• 出版年：January, 2014
• 年：2014
• 卷：65
• 期：1
• 页码：24-32
• 全文大小：2492 K

文摘

Interleukin (IL)-32 is a novel proinflammatory cytokine, which has been shown to play an important role in tumor growth and metastasis. Here, we discovered that IL-32 was aberrantly over-expressed in lung adenocarcinoma tissues and cell lines. Positive expression of IL-32 significantly correlated with the clinical staging, and lymph node and distant metastases. High expression of IL-32 was an independent indicator of poor prognosis in lung adenocarcinoma patients. Moreover, IL-32-facilitated cell migration and invasion in vitro was mediated through transactivation of the nuclear transcription factor (NF)-魏B signaling pathway and subsequent upregulation of matrix metalloproteinase (MMP)-2 and MMP9 expression. These studies demonstrate that IL-32 plays a role in the tumor-associated inflammatory microenvironment and that overexpression of IL-32 contributes to invasion and metastasis in primary lung adenocarcinoma, suggesting that it may have clinical utility as a prognostic biomarker and potential target for immunotherapy in lung adenocarcinoma.