CETP polymorphisms confer genetic contribution to centenarians of Hainan, south of China

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• 作者：Yun-Xia Zhang¹ ; ^# ; Ya Su² ; ^# ; Li Tang³ ; ^# ; Ze-Xing Yang³ ; Dai-Feng Zhou¹ ; Yi-Min Qiu¹ ; Wang-Wei Cai¹ ; ^{caiww591020@163.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Centenarians ; Polymorphisms of CETP ; Genetic contribution
• 刊名：Asian Pacific Journal of Tropical Medicine
• 出版年：2016
• 出版时间：September 2016
• 年：2016
• 卷：9
• 期：9
• 页码：872-876
• 全文大小：364 K

文摘

In this paper, we will discuss if the CETP polymorphism contributes to the centenarians in Hainan island.

Methods

We tested the TaqIB and I405V polymorphisms of CETP gene among 276 centenarians and 301 matched healthy individuals by AS-PCR and analyzed the data with SPSS software package (Version 19.0).

Results

Our data indicated that allele B1 and V have the significant differences between centenarians and healthy control groups with P < 0.001. Further analysis implied that genotypes B1B1 (P < 0.001, OR = 0.148, 95% CI = 0.095–0.230) and VV (P < 0.001 and OR = 0.353, 95% CI = 0.237–0.525) were significantly different between centenarians and matched controls. The combination of B and V, such as B1B1-II (P < 0.001, OR = 0.128, 95% CI = 0.049–0.329), B1B1-IV (P < 0.001, OR = 0.115, 95% CI = 0.056–0.237), B1B2-VV (P < 0.05, OR = 0.534, 95% CI = 0.310–0.920), and B2B2-VV (P < 0.001, OR = 0.198, 95% CI = 0.086–0.453) have significant differences between centenarians and matched healthy individuals from Hainan.

Conclusion

Our results implied that allele B1B1 and VV, as well as the combination B1B1-II, B1B1-IV, B1B2-VV and B2B2-VV may contribute to the longevity in centenarians of Hainan, south of China.