Induction and suppression of type I interferon responses by mink enteritis virus in CRFK cells

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• 作者：Xiaomei Zhang ; Jigui Wang ; Yaping Mao ; Ji Xi ; Yongle Yu ; Weiquan Liu ; ^{weiquan8@cau.edu.cn}
• 关键词：Mink enteritis parvovirus ; Type I interferon ; Nonstructural protein ; ORI-binding domain
• 刊名：Veterinary Microbiology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：199
• 期：Complete
• 页码：8-14
• 全文大小：1493 K
• 卷排序：199

文摘

MEV neither induced nor was sensitive to the effects of type I interferon. The nonstructural protein (NS1) of MEV inhibits IFN induction. The ORI-binding domain of NS1 protein suppresses IFNβ expression.