Delivery of dietary triglycerides to Caenorhabditis elegans using lipid nanoparticles: Nanoemulsion-based delivery systems
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- 作者：Daniel Colmenares ; Quancai Sun ; Peiyi Shen ; Yiren Yue ; D. Julian McClements ; Yeonhwa Park ; ypark@foodsci.umass.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：C. elegans ; Caernohabditis elegans ; CLA ; conjugated linoleic acid ; SOR ; surfactant-to-oil ratio
- 刊名：Food Chemistry
- 出版年：2016
- 出版时间：1 July 2016
- 年：2016
- 卷：202
- 期：Complete
- 页码：451-457
- 全文大小：1326 K
文摘
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A nanoemulsion-based method to deliver triglycerides to C. elegans was tested.
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C. elegans ingested triglyceride nanoparticles with particle size 40–500 nm.
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Ingestion of CLA nanoparticles by C. elegans significantly reduced fat accumulation.
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Nanoparticles may be applied to evaluate hydrophobic compounds in C. elegans.