Combining 1H NMR spectroscopy and multivariate regression techniques to quantitatively determine falsification of porcine heparin with bovine species
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- 作者：Yulia B. Monakhovaa ; b ; monakhova@spectralservice.de" class="auth_mail" title="E-mail the corresponding author ; Bernd W.K. Diehla
- 关键词：1H NMR spectroscopy ; Heparin ; Authenticity ; Chemometrics ; Multivariate regression
- 刊名：Journal of Pharmaceutical and Biomedical Analysis
- 出版年：2015
- 出版时间：10 November 2015
- 年：2015
- 卷：115
- 期：Complete
- 页码：543-551
- 全文大小：1035 K
文摘
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NMR spectroscopy and multivariate regression methods were used to control heparin animal origin.
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PLS and RR showed best performance with LOD and RMSEV below 2% and 1%, respectively.
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The developed method was applicable to heparinoid matrix (not purified heparin).
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The simple and cheap NMR method is recommended for screening of heparin authenticity regarding its origin based on chemomteric modelling.