Role of 3T multiparametric-MRI with BOLD hypoxia imaging for diagnosis and post therapy response evaluation of postoperative recurrent cervical cancers

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• 作者：Abhishek Mahajan^a ; ^b ; ^{abhishek.mahajan@kcl.ac.uk} ; ^{drabhishek.mahajan@yahoo.in} ; Reena Engineer^c ; Supriya Chopra^c ; Umesh Mahanshetty^c ; S.L. Juvekar^a ; S.K. Shrivastava^c ; Naresh Desekar^a ; M.H. Thakur^a
• 关键词：MPMRI ; multiparametric-MRI ; DCE ; dynamic contrast enhanced ; DWI ; diffusion weighted imaging ; 1HMRS ; proton magnetic resonance spectroscopy ; BOLD ; blood oxygen level dependent ; NEI ; negative enhancement integral ; ADC ; apparent diffusion coefficient ; PD-IDEAL ; proton density iterative decomposition of water and fat with echo asymmetric and least-squares estimation
• 刊名：European Journal of Radiology Open
• 出版年：2016
• 出版时间：2016
• 年：2016
• 卷：3
• 期：Complete
• 页码：22-30
• 全文大小：2323 K
• 卷排序：3

文摘

In operated cervix cancer, the accuracy of diagnosing vaginal vault/local recurrent lesions was higher at combined multiparametric MR imaging and conventional MR imaging (100%) than at conventional MR imaging (70%) or multiparametric MR imaging (96.7%) alone. We found a significant correlation between percentage tumor regression and pre-treatment parameters: NEI (p = 0.02), the maximum slope (p = 0.04), mADC value (p = 0.001) and amount of hypoxic fraction present in the pretherapy MRI (p = 0.01). Multiparametric and BOLD hypoxia MR Imaging are feasible and reliable in diagnosing post-operative recurrence in cervical cancer and should be applied when there is clinical suspicion of post-operative recurrence. Quantitative image features obtained at multiparametric-MRI with BOLD hypoxia imaging has potential to be an appropriate and reliable biologic target for radiation dose painting to optimize therapy in future.