Multivariable general linear regression models of non-collinear variables were fitted to assess the association of demographic (sex, age), nutritional (short-term energy intake, unintentional weight loss, body mass index), and clinical (cardiac and liver involvement, kidney function, C-reactive protein) parameters with serum prealbumin levels in 187 patients newly diagnosed with immunoglobulin light-chain amyloidosis.
Serum prealbumin levels were associated with C-reactive protein and short-term energy intake (P?<?0.001 for both). A significant association was also detected with age (P?=?0.023), serum creatinine (P?=?0.017), liver involvement (P?=?0.002), and peripheral edema (P?=?0.032). In a prespecified subgroup analysis (n?=?140) in patients with normal C-reactive protein level (<0.5?mg/dL), all other associations were confirmed. A significant relation was also observed with sex (P?=?0.022) and body mass index (P?=?0.041).
Serum prealbumin is associated with short-term energy intake independently of the presence of multiple-organ involvement and inflammation. Its serum levels should be always interpreted in light of its influencing factors, among which inflammation and liver and kidney functions appear predominant.