Early impairment of synaptic plasticity in patients with Down's syndrome

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• 作者：Fortunato Battaglia ; Angelo Quartarone ; Vincenzo Rizzo ; Maria Felice Ghilardi ; Aless ; ro Di Rocco ; Gaetano Tortorella ; Paolo Girl ; a
• 关键词：Transcranial magnetic stimulation ; LTP ; Down's syndrome
• 刊名：Neurobiology of Aging
• 出版年：2008
• 出版时间：August 2008
• 年：2008
• 卷：29
• 期：8
• 页码：1272-1275
• 全文大小：141 K

文摘

We investigated synaptic plasticity in persons with Down’ syndrome (DS) and control subjects used paired associative stimulation (PAS) protocol, a paradigm capable of producing long-term potentiation (LTP)-like changes in the sensorimotor system. After PAS, patients showed less LTP-like plasticity compared to control subjects. Abnormal motor cortex synaptic plasticity may play a role in the development of motor signs in DS.