Trinuclear trans-a2PtII complexes with two bridging 9-alkyladenine (A) ligands are reported.
PtII coordination to both N1 and N7 of A causes a large drop in pKa of the N6H2 group.
ΔpKa depends on the cross-linking pattern and the rotamer state of the central As.
Linkage isomers display different pKa values.