Connectivity patterns and rotamer states of nucleobases determine acid-base properties of metalated purine quartets
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- 作者：Marc Sven Lü ; tha ; c ; Eva Freisingerb ; freisinger@chem.uzh.ch" class="auth_mail" title="E-mail the corresponding author ; Gunnar Kampfa ; c ; Marta Garijo Anorbea ; Rolf Griesserc ; Bert P. Operschallc ; Helmut Sigelc ; helmut.sigel@unibas.ch" class="auth_mail" title="E-mail the corresponding author ; Bernhard Lipperta ; bernhard.lippert@tu-dortmund.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：Acidity constants ; Adenine ; Linkage isomers ; Platinum ; Quartet formation
- 刊名：Journal of Inorganic Biochemistry
- 出版年：2015
- 出版时间：July 2015
- 年：2015
- 卷：148
- 期：Complete
- 页码：93-104
- 全文大小：1085 K
文摘
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Trinuclear trans-a2PtII complexes with two bridging 9-alkyladenine (A) ligands are reported.
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PtII coordination to both N1 and N7 of A causes a large drop in pKa of the N6H2 group.
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ΔpKa depends on the cross-linking pattern and the rotamer state of the central As.
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Linkage isomers display different pKa values.