Four new quassinoids from the roots of Eurycoma longifolia Jack

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• 作者：Dali Meng ; Xin Li ; Lingfei Han ; Lulu Zhang ; Weiwei An ; Xian Li
• 关键词：Quassinoids ; Cytotoxic activity ; Single crystal X-ray diffraction
• 刊名：Fitoterapia
• 出版年：January, 2014
• 年：2014
• 卷：92
• 期：Complete
• 页码：105-110
• 全文大小：727 K

文摘

Seven compounds were isolated from the roots of Eurycoma longifolia, and characterized by comprehensive analysis of 1D and 2D NMR experiments along with single crystal X-ray diffraction. Among them, four new quassinoids were identified and three of them were diastereomers for each other. Compounds 1-7 were evaluated for cytotoxicities against HT-29, MCF-7, LOVO, BGC-823, MGC-803, HepG2, HeLa, and A549 cancer cell lines. Compounds 2 and 5 exhibited the lowest IC₅₀ values of 24.9 渭M, 11.8 渭M, and 44.1 渭M, 14.1 渭M towards MCF-7, MGC-803 cancer cell lines, respectively, while compound 6 exhibited moderate cytotoxicity towards all the selected cancer cell lines.