Nut consumption is associated with lower incidence of type 2 diabetes: The Tehran Lipid and Glucose Study

详细信息    查看全文

• 作者：G. Asghari^a ; Z. Ghorbani^a ; ^b ; P. Mirmiran^a ; ^{mirmiran@endocrine.ac.ir} ; ^{parvin.mirmiran@gmail.com} ; F. Azizi^c
• 关键词：Incidence ; Nuts ; Type 2 diabetes
• 刊名：Diabetes & Metabolism
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：43
• 期：1
• 页码：18-24
• 全文大小：736 K
• 卷排序：43

文摘

Nuts are rich in unsaturated fatty acids as well as other bioactive constituents. The present study investigated the association between nut consumption and the incidence of type 2 diabetes mellitus (T2DM) in a Middle Eastern population.MethodsThe study was conducted within the framework of the Tehran Lipid and Glucose Study (TLGS), in which 1984 participants (920 men and 1064 women) free of DM, aged ≥ 20 years, were followed from phase III (2005–2008) to phase V (2011–2014). Dietary data were obtained from valid and reliable food-frequency questionnaires at baseline. Using multiple logistic regression, odds ratios (ORs) and 95% confidence intervals (CIs) were calculated, with adjustments for age, gender, BMI, serum cholesterol and triglycerides, smoking and energy intake.ResultsStudy participants’ means ± SD of age and of BMI were 40.1 ± 13.1 years and 27.0 ± 4.8 kg/m2, respectively. The median ± SE of their total daily consumption of nuts was 1.19 ± 0.11 servings. After 6.2 ± 0.7 years of follow-up, 150 cases of T2DM were confirmed. On comparing those who consumed ≥ 4 servings/week with those who consumed < 1 serving/week, the age-/energy-adjusted OR of incident T2DM for total nut consumption was 0.64 (95% CI: 0.36–1.12; P for trend = 0.03). In a fully adjusted model, nut consumption was associated with a lower risk of T2DM, and the ORs (95% CIs) of risk for those consuming 2–3.99 and ≥ 4 servings/week of nuts were 0.51 (0.26–0.97) and 0.47 (0.25–0.90), respectively, compared with those consuming < 1 serving/week (P < 0.001 for trend).ConclusionOur findings suggest that consuming ≥ 4 servings/week of nuts reduced the risk of T2DM compared with < 1 serving/week.