Lack of association between polymorphisms of the coagulation factor VII and myocardial infarction in middle-aged Spanish men

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• 作者：Batalla ; Alberto ; Alvarez ; Ruth ; Reguero ; Juliá ; n R. ; Gonzá ; lez ; Pelayo ; Alvarez ; Victoria ; et. al.
• 关键词：Factor VII gene ; Polymorphism ; Myocardial infarction ; Middle-aged patients
• 刊名：International Journal of Cardiology
• 出版年：2001
• 出版时间：September - October, 2001
• 年：2001
• 卷：80
• 期：2-3
• 页码：209-212
• 全文大小：43.3 K

文摘

In order to determine the role of two polymorphisms in the factor VII gene (R353Q and intron 7 hypervariable region) in the susceptibility to develop early myocardial infarction, a total of 175 patients with acute myocardial infarction aged 50 years or less (mean age 41±7 years) and 200 controls (average age 42±6) without cardiovascular disease were genotyped for these polymorphisms. Gene and genotype frequencies did not differ between patients and controls. Although the 353-QQ genotype was at a higher frequency among controls (4 % ) compared to patients (1 % ), the difference did not reach statistical significance. Carriers of the H7-allele (intron 7 polymorphism) were at a slightly higher frequency among patients (51 vs. 43 % ; P