Study on the preparation and biodistribution of ^99mTc-HMIBP

详细信息    查看全文

• 作者：Xue-Hua GUO ; Shi-Neng LUO ; Hong-Yong WANG ; Lian ZHOU ; Min-Hao XIE ; Wan-Zhong YE ; Min YANG ; Yang WANG
• 关键词：Bone-imaging agent ; ^99mTc-labeled HMIBP ; Biodistribution
  CLC number ; R817
• 刊名：Nuclear Science and Techniques
• 出版年：2006
• 出版时间：October 2006
• 年：2006
• 卷：17
• 期：5
• 页码：285-288
• 全文大小：307 K

文摘

^99mTc-HMIBP, a new bone-imaging agent, was prepared by the reduction of ^99mTc-pertechnetate in the presence of SnCl₂·2H₂O. The effects of the amounts of SnCl₂·2H₂O and HMIBP and the pH value on the labeling yield and radiochemical purity of ^99mTc-HMIBP were investigated. When the amounts of SnCl₂·2H₂O and HMIBP were more than 10 μg and 2.5 mg, respectively, the pH value was between 2 and 7, and the labeling reaction continued for 10 min, both labeling yield and radiochemical purity of ^99mTc-HMIBP were more than 90 % . The biodistribution in rats and bone scan in rabbits were also studied. The results showed that the bone uptake is up to 7.94 % ID/g at 30 min after injection of ^99mTc-HMIBP, bone-to-muscle and bone-to-blood uptake ratios were 20.89 and 16.89, respectively. The clear bone image was obtained at 120 min after injection of ^99mTc-HMIBP and clearance in soft tissue was visible. All of the above-mentioned results suggested that ^99mTc-HMIBP may be a potential bone-imaging agent.