Arterial calcification: A new perspective?
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- 作者：R Nicoll ; rachelnicoll25@gmail.com ; M Henein
- 关键词：Arterial calcification ; Response to injury ; Plaque rupture
- 刊名：International Journal of Cardiology
- 出版年：2017
- 出版时间：1 February 2017
- 年：2017
- 卷：228
- 期：Complete
- 页码：11-22
- 全文大小：606 K
- 卷排序：228
文摘
Researchers consider arterial calcification to be a progressive pathology which must be treated. Arterial calcification has been considered as ‘sub-clinical atherosclerosis’, yet lipid-lowering fails to regress it. Both presence and absence of coronary calcification predict plaque rupture and CV events. We hypothesise that calcification develops as an immune response to endothelial injury. We should be attempting to prevent all causes of endothelial injury, including oxidative stress.