Expansion of CD14⁺CD16⁺ monocytes producing TNF-¦Á in complication-free diabetes type 1 juvenile onset patients

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• 作者：Jolanta My?liwska ; Marcin Smardzewski ; Natalia Marek-Trzonkowska ; Ma?gorzata My?liwiec ; Krystyna Raczy¨½ska
• 关键词：Monocyte subsets ; Diabetes mellitus ; TNF-¦Á
• 刊名：Cytokine
• 出版年：2012
• 出版时间：October, 2012
• 年：2012
• 卷：60
• 期：1
• 页码：309-317
• 全文大小：715 K

文摘

We concentrated on the complication-free phase of juvenile onset type 1 diabetes mellitus (T1DM) searching for associations between concentration of inflammatory factors TNF-¦Á, CRP and VEGF and two monocyte subsets the CD14⁺⁺CD16^? and CD14⁺CD16⁺. We analysed a randomly selected group of 150 patients without complications (disease duration 2.74 ¡À 2.51 years) at the start of the project and 5 years later. They were compared with 24 patients with retinopathy (6.53 ¡À 3.39 years of disease) and 30 healthy volunteers. Our results indicate that in the complication-free period the concentration of TNF-¦Á significantly increased and continued to increase after retinopathy was established. After 5 years the percentage and absolute number of CD14⁺CD16⁺ monocytes doubled in complication-free patients. Our study indicates that the size of CD14⁺CD16⁺ monocyte subset may be used alternatively to CRP values as an indicator of inflammation grade. Our results imply the necessity of trials using anti-TNF-¦Á therapy in the complication-free phase of the disease.