An N-acetylglucosamine containing glycopeptide — synthesis and structure assignment
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- 作者：Saha ; Uttam K. ; Griffith ; Lee S. ; Rademann ; Jö ; rg ; Geyer ; Armin ; Schmidt ; Richard R.
- 关键词：O-Glycopeptides ; O-Linked N-acetylglucosamine ; Synthesis ; Conformational analysis
- 刊名：Carbohydrate Research
- 出版年：1997
- 出版时间：October 28, 1997
- 年：1997
- 卷：304
- 期：1
- 页码：21-28
- 全文大小：572 K
文摘
A nonapeptide sequence alignment known to be O-glycosylated at serine and/or threonine residues by N-acetylglucosamine (2-acetamido-2-deoxy-d-glucose) was chemically synthesized with and without O-GlcNAc residues. A detailed conformational analysis was performed which displays the preferred conformation of the peptide backbone and the influence of the sugar residues.