Inflammatory and fatty lesions in the spine and sacroiliac joints on whole-body MRI in early axial spondyloarthritis—3-Year data of the ESTHER trial

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• 作者：In-Ho Song^a ; ^{in-ho@gmx.de" class="auth_mail" title="E-mail the corresponding author} ; ^{in-ho.song@charite.de" class="auth_mail" title="E-mail the corresponding author} ; Kay-Geert Hermann^b ; Hildrun Haibel^a ; Christian E. Althoff^b ; Denis Poddubnyy^a ; Joachim Listing^c ; Anja Weiß ; ^c ; Bruce Freundlich^d ; Ekkehard Lange^e ; Martin Rudwaleit^a ; ^f ; Joachim Sieper^a
• 关键词：Ankylosing spondylitis ; axial spondyloarthritis ; magnetic resonance imaging ; radiographic progression ; TNF-alpha-blocker
• 刊名：Seminars in Arthritis and Rheumatism
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：45
• 期：4
• 页码：404-410
• 全文大小：817 K

文摘

To assess the relationship between active inflammation and development of chronic lesions in the spine and sacroiliac (SI)-joints on MRI in early axial spondyloarthritis (SpA) during treatment with etanercept.

Methods

Here, we analyzed the 41 patients of the ESTHER trial, who were treated with etanercept over 3 continuous years and of whom MRIs were available for baseline, year 2, and year 3. MRIs were scored for active inflammation (STIR sequences) and chronic changes (T1 sequence) such as fatty lesions, erosions, and ankylosis in the SI joints and spinal vertebral units (VUs).

Results

The mean fatty lesion scores increased between baseline and year 2 both in the spine (1.13 at baseline vs. 1.40 at year 2, p = 0.0254) and in the SI joints (4.76 at baseline vs. 5.46 at year 2, p = 0.27), but we found no further increase of the fatty lesion score between years 2 and 3. New fatty lesions at years 2 and 3 developed nearly exclusively in SI joint quadrants and VUs in which active MRI inflammation was present at baseline. Fatty lesions disappeared only in 3 SI joint quadrants and in none of VUs at years 2 and 3. Erosion and ankylosis scores remained unchanged.

Conclusion

Our data indicate a relationship between the presence of active MRI inflammation and the new development of fatty lesions. Furthermore, there was no increase of fatty lesions during continuous treatment of axial SpA patients with etanercept after successful suppression of active inflammation. Whether this is predictive of stopping radiographic progression needs to be further investigated.

Significance and Innovations

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This is the first study prospectively following inflammatory lesions, including fatty lesions on MRI of spine and sacroiliac joints of patients with early axial SpA treated over 3 years of continuous treatment with a TNF-inhibitor.

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No further increase of fatty lesions between year 2 and year 3 was found in early axial SpA patients treated continuously with etanercept.

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Our data indicate a strong relationship between the presence of active MRI inflammation and the new development of fatty lesions.

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Whether this is predictive of stopping radiographic progression needs to be further investigated.