Evaluation of radiosurgery techniques-Cone-based linac radiosurgery vs tomotherapy-based radiosurgery
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- 作者：Ho Yin Yip ; M.Sc. ; C.M.D.? ; hoyinyip@yahoo.com.hk ; Gary.HY.Yip@hksh.com ; Wing Lun A. Mui ; M.Sc. ; C.M.D.? ; Joseph W.Y. Lee ; M.Sc. ; C.M.D.? ; Winky Wing Ki Fung ; M.Phil ; C.M.D.? ; Jocelyn M.T. Chan ; M.Sc ; C.M.D.? ; G. Chiu ; M.H.M.? ; Maria Y.Y. Law ; Ph.D.&dagger ;
- 关键词：Cone-based Linac radiosurgery ; Tomotherapy-based radiosurgery ; Dose conformity ; Dose homogeneity ; Dose fall-off
- 刊名：Medical Dosimetry
- 出版年：2013
- 出版时间：Summer, 2013
- 年：2013
- 卷：38
- 期：2
- 页码：184-189
- 全文大小：463 K
文摘
Performances of radiosurgery of intracranial lesions between cone-based Linac system and Tomotherapy-based system were compared in terms of dosimetry and time. Twelve patients with single intracranial lesion treated with cone-based Linac radiosurgery system from 2005 to 2009 were replanned for Tomotherapy-based radiosurgery treatment. The conformity index, homogeneity index (HI), and gradient score index (GSI) of each case was calculated. The Wilcoxon matched-pair test was used to compare the 3 indices between both systems. The cases with regular target (n = 6) and those with irregular target (n = 6) were further analyzed separately. The estimated treatment time between both systems was also compared. Significant differences were found in HI (p = 0.05) and in GSI (p = 0.03) for the whole group. Cone-based radiosurgery was better in GSI whereas Tomotherapy-based radiosurgery was better in HI. Cone-based radiosurgery was better in conformity index (p = 0.03) and GSI (p = 0.03) for regular targets, whereas Tomotherapy-based radiosurgery system performed significantly better in HI (p = 0.03) for irregular targets. The estimated total treatment time for Tomotherapy-based radiosurgery ranged from 24 minutes to 35 minutes, including 15 minutes of pretreatment megavoltage computed tomography (MVCT) and image registration, whereas that for cone-based radiosurgery ranged from 15 minutes for 1 isocenter to 75 minutes for 5 isocenters. As a rule of thumb, Tomotherapy-based radiosurgery system should be the first-line treatment for irregular lesions because of better dose homogeneity and shorter treatment time. Cone-based Linac radiosurgery system should be the treatment of choice for regular targets because of the better dose conformity, rapid dose fall-off, and reasonable treatment time.