Quantitative MRI assessment of a novel direction modulated brachytherapy tandem applicator for cervical cancer at 1.5 T

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• 作者：Abraam S. Soliman^a ; ^b ; Alyaa Elzibak^a ; ^c ; Harry Easton^a ; James Y. Kim^a ; ^b ; Dae Yup Han^a ; ^d ; Habib Safigholi^a ; ^b ; Shahram Mashouf^a ; ^c ; Amir Owrangi^a ; ^c ; Ananth Ravi^a ; ^c ; William Y. Song^a ; ^b ; ^c ; ^{william.song@sunnybrook.ca" class="auth_mail" title="E-mail the corresponding author}
• 关键词：MRI ; Cervical cancer ; Brachytherapy ; DMBT ; Tandem applicator
• 刊名：Radiotherapy and Oncology
• 出版年：2016
• 出版时间：September 2016
• 年：2016
• 卷：120
• 期：3
• 页码：500-506
• 全文大小：1594 K

文摘

The purpose of this work is to quantitatively investigate the artifacts and image distortions induced in the MR images by a recently proposed direction modulated brachytherapy (DMBT) tandem applicator prototype. This new MRI-compatible applicator allows better sparing of organs-at-risk (OAR) for cervical cancer patients, while providing conformal dose distributions to target volumes.

Materials and methods

Specific phantom and tools were designed and manufactured for this study. The phantom was filled with a tissue-like solution and MR images were acquired with clinical protocols as per GEC-ESTRO recommendations. Images were obtained at 6 different orientations that mimic possible clinical settings and full-width-at-half-maximum (FWHM) was recorded at multiple locations/angles. The accuracy of detecting the centerline of the tandem was assessed using a novel radial-fiducials mount.

Results

FWHM from all line profiles at all angles and all orientations was 6.14 ± 0.7 mm (compared to 6 mm of the actual DMBT tandem diameter). The in-plane spatial-shift observed at para-axial and para-sagittal views was less than 0.5 mm.

Conclusions

This work demonstrated that the novel DMBT tandem applicator prototype has minimal artifact in T₂-weighted images employed in clinical practice, suggesting the applicator might be a good candidate for MRI-guided adaptive brachytherapy.