Conformational equilibrium of talin is regulated by anionic lipids
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- 作者：Xin Ye ; Mark A. McLean ; Stephen G. Sligar
- 关键词：ECM ; extracellular matrix ; PIP2 ; phoshpatidylinositol-4 ; 5-bisphosphate ; PI4P ; phoshpatidylinositol-4-phosphate ; FERM ; band 4.1/ezrin/radixin/moesin ; THD ; talin head domain ; TM ; transmembrane ; OMC ; outer membrane clasp ; IMC ; inner membrane clasp ; MD ; Molecular Dynamics ; TAMRA ; Tetramethylrhodamine-5-(and -6) C2 maleimide ; MSP ; Membrane Scaffold Protein ; UA ; Uniblue A
- 刊名：Biochimica et Biophysica Acta (BBA)-Biomembranes
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：1858
- 期：8
- 页码：1833-1840
- 全文大小：1014 K
文摘
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Anionic lipids regulate the conformational equilibrium of membrane bound THD.
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The identity of the anionic headgroup is important in the mechanism of regulation.
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PIP2 is the most efficient at promoting a change in the conformational equilibrium.