PET/CT in initial staging and therapy response assessment of early mediastinal lymphoma

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• 作者：Noha Hosam EL Din Behairy ; Tarek Ahmed Rafaat ; Amr Salah EL Din El Nayal ; Magdy Ibrahim Bassiouny
• 关键词：PET/CT ; Hodgkin&rsquo ; s lymphoma ; Non-Hodgkin&rsquo ; s lymphoma ; Mediastinum ; Therapy response
• 刊名：The Egyptian Journal of Radiology and Nuclear Medicine
• 出版年：March, 2014
• 年：2014
• 卷：45
• 期：1
• 页码：61-67
• 全文大小：1042 K

文摘

Objective

To detect accuracy of PET/CT in the initial staging, response after the first line and end of treatment in early mediastinal lymphoma patients compared to contrast CT.

Materials and methods

We studied 50 patients with pathologically proven lymphoma with a mean age = 27.5. All patients were at early stage. All patients performed CT and PET/CT for initial staging, after the first course of chemotherapy (after 4-6 weeks) and at the end of treatment (after 2-4 months).

Results

PET/CT upstaged 5 cases. At first line of treatment, PET/CT and CECT were agreeable in 32% of cases. PET/CT showed 100% sensitivity, 96.7% specificity, 95% positive predictive value and 100% negative predictive value. At the end of treatment both methods showed a 46% agreement. PET/CT was statistically significant in the follow up of hilar and axillary lymph nodes. PET/CT showed 100% sensitivity and specificity; compared to 62.5% sensitivity and 97.6% specificity for CECT in detection of extra-nodal disease sites.

Conclusion

PET/CT proved higher sensitivity and specificity over CECT. The major strength of PET/CT over CECT was its higher ability for detection of extra-nodal sites of lymphoma and excluding active disease in residual nodal mass lesions on follow up.