Low-grade myofibroblastic sarcoma of the larynx: A case report

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• 作者：Bé ; lgica M&aacute ; rquez-Lobo ; ^{bomzlo59@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Rafael J. Luque-Barona ; Ana M. Perab&aacute ; -Ruiz ; Cesar Ramí ; rez-Tortosa
• 关键词：Low-grade myofibroblastic sarcoma ; Sarcoma of the vocal cord ; Head and neck
• 刊名：Revista Española de Patología
• 出版年：2016
• 出版时间：October-December 2016
• 年：2016
• 卷：49
• 期：4
• 页码：259-262
• 全文大小：1513 K

文摘

Low-grade myofibroblastic sarcoma is a rare neoplasm, with an incidence of less than 1% and a predilection for the head and neck area.

We report a case occurring in a 55 year-old male and in an unusual location: the anterior commissure of the larynx. The patient presented with short-term dysphonia. A nodular lesion on the right vocal cord was detected and a biopsy and subsequent resection of the mass was performed. The nodule consisted of a spindle cell fascicular proliferation in a dense collagenous matrix. Moderate atypia, mitotic activity (>10X10HPF) and a proliferation index of 10% were noted. Immunohistochemistry showed positivity for vimentin, muscle-specific actin (HHF35) and negativity fordesmin, ALK, p53, cytokeratins (AE1/AE3, 5/6 and 18), EMA, GFAP, S100, CD34, CD68 and CD99.