Protection against irradiation-induced damage to salivary glands by adrenergic agonist administration
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- 作者：Nagler ; Rafael M. ; Laufer ; Dov
- 关键词：Adrenergic agonists ; Irradiation ; Protection ; Saliva ; Salivary gland
- 刊名：International Journal of Radiation Oncology*Biology*Physics
- 出版年：1998
- 出版时间：January 15, 1998
- 年：1998
- 卷：40
- 期：2
- 页码：477-481
- 全文大小：602 K
文摘
Purpose: Irradiation [IR]-induced damage to major salivary glands is an entity first described at the beginning of our century, yet its underlying mechanism is still enigmatic. Exposure of the salivary glands to IR is often inevitable when delivering radiotherapy for malignancies of the head and neck region. Frequently, this results in rapidly developing, life-long severe xerostomia for which no adequate prevention or treatment is available. The purpose of this study was to examine the role of secretion granules in serous cells of the parotid (P) and submandibular (SM) glands as mediators in the IR-induced salivary damage. Functional parameters (flow rate and gland weight), and total body weight were examined at both early term (4 days) and extended term (2 months) post-IR in male Wistar rats exposed to 15 Gy of head and neck irradiation following stimulation for granule secretion (degranulation).