Ghrelin O-acyltransferase (GOAT) enzyme is overexpressed in prostate cancer, and its levels are associated with patient's metabolic status: Potential value as a non-invasive biomarker
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- 作者：Daniel Hormaechea-Agullaa ; b ; c ; d ; e ; Enrique Gó ; mez-Gó ; meza ; c ; f ; Alejandro Ibá ; ñ ; ez-Costaa ; b ; c ; d ; e ; Julia Carrasco-Valientea ; c ; f ; Esther Rivero-Corté ; sa ; b ; c ; d ; e ; Fernando L-Ló ; peza ; b ; c ; d ; e ; Sergio Pedraza-Arevaloa ; b ; c ; d ; e ; José ; Valero-Rosaa ; c ; f ; Rafael Sá ; nchez-Sá ; ncheza ; c ; g ; Rosa Ortega-Salasa ; c ; g ; Marí ; a M. Morenoa ; c ; g ; Manuel D. Gahetea ; b ; c ; d ; e ; José ; Ló ; pez-Mirandaa ; c ; d ; h ; Marí ; a J. Requenaa ; c ; f ; Justo P. Castañ ; oa ; b ; c ; d ; e ; justo@uco.es" class="auth_mail" title="E-mail the corresponding author ; Raú ; l M. Luquea ; b ; c ; d ; e ; raul.luque@uco.es" class="auth_mail" title="E-mail the corresponding author
- 关键词：GOAT-enzyme ; Ghrelin ; Prostate cancer ; Biomarker ; Diagnosis ; Diabetes
- 刊名：Cancer Letters
- 出版年：2016
- 出版时间：1 December 2016
- 年：2016
- 卷：383
- 期：1
- 页码：125-134
- 全文大小：2618 K
文摘
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GOAT-enzyme is overexpressed in prostate cancer (PCa) vs. normal prostate tissues.
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Plasma and urine levels of GOAT-enzyme are elevated in patients with prostate cancer.
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GOAT-enzyme is secreted by prostate cancer cells.
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GOAT levels correlated with aggressiveness and metabolic conditions in PCa-patients.
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GOAT-enzyme might be a promising non-invasive diagnosis biomarker in PCa.