Prefrontal white matter pathology in air pollution exposed Mexico City young urbanites and their potential impact on neurovascular unit dysfunction and the development of Alzheimer's disease
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- 作者：Lilian Calderó ; n-Garcidueñ ; asa ; b ; lilian.calderon-garciduenas@umontana.edu" class="auth_mail" title="E-mail the corresponding author ; Rafael Reynoso-Roblesc ; Javier Vargas- Martí ; nezb ; Aline Gó ; mez-Maqueo-Chewd ; Beatriz Pé ; rez-Guillé ; c ; Partha S. Mukherjeee ; Ricardo Torres-Jardó ; nf ; George Perryg ; Angé ; lica Gó ; nzalez-Macielc
- 关键词：Air pollution ; Alzheimer ; BBB ; Children ; Dogs ; Endothelial damage ; PM2.5 ; Nanosize particles ; Neurovascular unit ; Tight junctions
- 刊名：Environmental Research
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：146
- 期：Complete
- 页码：404-417
- 全文大小：4647 K
文摘
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The prefrontal white matter is a target of air pollution.
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Tight junctions, key neurovascular unit elements, are abnormal in young urbanites.
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Identifying neurovascular dysfunction biomarkers is key for pediatric neuroprotection.
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Early characterization of NVU damage may provide a fresh insight into AD pathogenesis.