Relationship of white and gray matter abnormalities to clinical and genetic features in myotonic dystrophy type 1
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- 作者：Stefano Zanignia ; b ; Stefania Evangelistia ; b ; Maria Pia Giannoccarob ; Federico Oppic ; Roberto Podac ; Antonio Giorgiod ; Claudia Testaa ; b ; David Neil Mannersa ; b ; Patrizia Avonib ; c ; Laura Ludovica Gramegnaa ; b ; Nicola De Stefanod ; Raffaele Lodia ; b ; raffaele.lodi@unibo.it" class="auth_mail" title="E-mail the corresponding author ; Caterina Tonona ; b ; 1 ; Rocco Liguorib ; c ; 1
- 关键词：myotonic dystrophy type 1 ; DTI ; TBSS ; VBM ; cortical thickness
- 刊名：NeuroImage: Clinical
- 出版年：2016
- 出版时间：2016
- 年：2016
- 卷：11
- 期：Complete
- 页码：678-685
- 全文大小：1370 K
文摘
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We investigated DM1 brain abnormalities with TBSS, VBM and cortical thickness analysis.
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White matter lesion refilling has been performed to improve voxel-wise analyses.
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All patients have been evaluated using a clinical scale created ad hoc for DM1.
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DM1 patients present diffuse white and cortical-subcortical gray matter disruption.
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White matter differences are correlated with clinical and genetic features.