Cardioprotective effect of aqueous, ethanol and aqueous ethanol extract of Aerva lanata (Linn.) against doxorubicin induced cardiomyopathy in rats

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• 作者：Paramasivam Ragavendran ; Dominic Sophia ; Chinthamony Arulraj ; Velliyur Kanniappan Gopalakrishnan ; ^{vkgopalakrishnan@gmail.com}
• 关键词：Cardiotoxicity ; Doxorubicin ; Serum biomarkers ; Enzymatic antioxidants ; Non-enzymatic antioxidants ; Lipid peroxidation ; Membrane bound enzymes
• 刊名：Asian Pacific Journal of Tropical Biomedicine
• 出版年：2012
• 出版时间：January, 2012
• 年：2012
• 卷：2
• 期：1_supp_S
• 页码：S212-S218
• 全文大小：1K

文摘

Objective

To evaluate the cardioprotective effect of aqueous, ethanol and aqueous ethanol extract of Aerva lanata (A. lanata) against doxorubicin induced cardiomyopathy in Wistar rats.

Methods

In this study, cardioprotective effect of aqueous, ethanol and aqueous ethanol extract of A. lanata against doxorubicin induced cardiomyopathy rats at the dosage of 200 mg/kg body weight for 28 days and also compared with standard allopathic drug aspirin. At the end of 28 days, enzymatic antioxidants, non-enzymatic antioxidants, lipid peroxidation, membrane bound enzymes were estimated in tissue homogenate. Cardiac biomarkers such as LDH, AST, ALT and lipid profiles such as cholesterol, triglycerides, HDL, LDL and VLDL were estimated in serum. Histopathology of heart samples was also performed.

Results

It was shown that all the three extracts of A. lanata has cardioprotective activity (P<0.05) similar to that of aspirin. There are no significant changes between groups VI, VII and VIII with group I. These results implied that A. lanata does not contain toxic substances.

Conclusions

By all these findings A. lanata has showed significant cardioprotective activity, which provides scientific proof of these traditional values.