Amelioration of cadmium- and mercury-induced liver and kidney damage in rats by genetically engineered probiotic Escherichia coli Nissle 1917 producing pyrroloquinoline quinone with oral supplementation of citric acid
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- 作者：Ruma Raghuvanshi ; M.Sc. ; Archana Chaudhari ; M.Sc. ; G. Naresh Kumar ; Ph.D. ; gnaresh_k@yahoo.co.in" class="auth_mail" title="E-mail the corresponding author
- 关键词：Cadmium ; Mercury ; Heavy metal toxicity ; Citric acid ; Pyrroloquinoline quinone ; Probiotic E. coli Nissle 1917
- 刊名：Nutrition
- 出版年：2016
- 出版时间：November-December 2016
- 年：2016
- 卷：32
- 期：11-12
- 页码：1285-1294
- 全文大小：4347 K
文摘
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Cadmium (Cd) and mercury (Hg) toxicity are reduced by probiotic Escherichia coli Nissle, citric acid, and pyrroloquinoline quinone (PQQ).
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EcN-20 secretes PQQ along with external citric acid reduces Cd and Hg toxicity.
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Artificial citrate operon was incorporated into EcN-20 to produce 2 mM citric acid.
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Citric acid secretion by EcN-21 is insufficient to reduce Cd and Hg toxicity.