Formation of size-tuneable biodegradable polymeric nanoparticles by solvent displacement method using micro-engineered membranes fabricated by laser drilling and electroforming
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- 作者：Rahimah Othmana ; b ; R.Othman@lboro.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Goran T. Vladisavljevića ; G.Vladisavljevic@lboro.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Hamed Shahmohamadic ; Zoltan K. Nagya ; d ; R.G. Holdicha
- 关键词：Membrane dispersion cell ; Computational fluid dynamics ; Nanoprecipitation ; Biodegradable polycaprolactone nanoparticles ; Microfabricated membrane ; Micromixing
- 刊名：Chemical Engineering Journal
- 出版年：2016
- 出版时间：15 November 2016
- 年：2016
- 卷：304
- 期：Complete
- 页码：703-713
- 全文大小：2250 K
文摘
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Size-tuneable NPs were formed by nanoprecipitation using microengineered membrane.
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A good micromixing favoured nucleation and led to a reduction in the particle size.
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The minimum particle size was 159 nm with a polydispersity index (PDI) of 0.107.
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Membrane with ringed operating area provided better performance than full membrane.
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Laser-drilled pores led to smaller NPs than conical nickel electroformed pores.